11 September 1683, Rome. The citizens of the city wait anxiously for the outcome of the battle for Vienna as Ottoman forces lay siege to the defenders of Catholic Europe. Meanwhile, a suspected outbreak of plague causes a famous Roman tavern to be placed under quarantine. One of its detainees, the mysterious Atto Melani, a spy in the service of France, discovers a secret passage leading deep into the Roman underworld. A plot to assassinate the pope and plans to use the plague as a weapon of mass destruction in the battle between Islam and the West are discovered.
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